A: Make sure you fulfill your obligation to take care of your cat by removing waste from the box at least once per day and keep the surrounding area clean. If the box is clean, make sure it’s located in a place that is easy to access, but that also provides a modicum of privacy. If you have other pets, be sure they’re not chasing your cat away from the box. If you can rule out environmental and behavioral factors, then the source of the problem may be a medical one. If no other explanation seems likely, it’s time to visit the veterinarian. Describe the behavior to your vet so he or she can rule out or diagnose any medical problem that might be causing the litter box issue.