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    Skeletal abnormalities, such as hip dysplasia, hypertrophic osteodystrophy, Legg-Calve-Perthes disease, patellar luxation and osteochondritis dissecans, often become evident in puppyhood. Lameness of one or more legs is the major sign, with other signs such as fever accompanying some disorders. If limping in a puppy persists, see your veterinarian for a diagnosis. Treatment may include strict rest, a change in diet, pain medication and possibly surgery.